Carla Sozzani served as editor-in-chief for all of Italian Vogue's special issues and in 1986, she was appointed by Alexander Liberman as editor-at-large for American Vogue in Italy. In 1987, Sozzani launched and edited the Italian edition of Elle. In 1990, she founded the Galleria Carla Sozzani at 10 Corso Como in Milan. The gallery primarily focused on photography and published exhibition catalogues and books on the work of Walter Albini, Pierre Cardin, Rudi Gernreich, Paco Rabanne, as well as numerous photographers. She subsequently oversaw more than 250 exhibitions of photography and design, presenting the works of artists such as Man Ray, Horst, Annie Leibovitz, Helmut Newton, David La Chapelle, just to name a few.
In 2002, she opened 10 Corso Como Comme des Garçons in Tokyo a co-venture store with Rei Kawakubo. In 2008, in a joint venture with Samsung Group, she created 10 Corso Como in Seoul, a three-story location combining fashion, art, design, and cuisine, designed by Kris Ruhs. In 2012, 10 Corso Como opened its second location in Seoul, 10 Corso Como. In 2013, Sozzani partnered with Trendy International Group to bring the 10 Corso Como concept to China. The new 10 Corso Como Shanghai opened in a freestanding glass building, featuring photography, fashion, design, music, cuisine, a pastry café, and an outdoor terrace surrounded by plants.